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The Drug-Induced Respiratory Disease Website

Philippe Camus 2012- v2

Pascal Foucher - Philippe Camus 1997- v1

Department of Pulmonary Medicine and Intensive Care University Hospital Dijon France

Contribution: Ph Bonniaud, N Baudouin, A Fanton, C Camus, N Favrolt, M Guerriaud, L Jacquet

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ACE inhibitors-ACEI

I.b I.c IV.a IV.d V.b V.d VIII.a VIII.q IX.e X.d XVIII.l
5

ATRA

I.b I.k II.a II.b II.f II.k III.a V.a V.m VI.a VI.d XII.c
4

Abacavir

I.a I.f II.a II.b IV.d X.a XV.d
2

Abciximab

III.a X.f
3

Acebutolol

I.b I.d V.a V.d
2

Acetazolamide

II.a X.f
1

Acetylcysteine

IV.a VIII.a X.f
2

Acitretin

II.b X.c
1

Acrylate cement

II.b VI.h VI.t XVIII.m
3

Acupuncture

V.f
2

Acyclovir

I.b V.a
1

Adalimumab

I.b I.g IV.a V.m X.b X.k XI.e XVII.e
3

Adenosine

IV.f XI.b XII.m
1

Adenosine 5'-triphosphate

XI.b
1

Adrenaline-Epinephrine

II.a II.d II.i XI.b XI.d XII.e XII.f XII.g XII.j
3

Aflibercept

VI.a
1

Albumin

II.a X.f
1

Alcohol (ethanol)

II.b II.g IV.a VI.l IX.d XI.b XI.e XI.g XI.h XI.y XI.ae
5

Alemtuzumab

II.a II.b III.a XVII.i
1

Alendronate

VIII.d XI.af XV.bf
2

Alglucerase

VI.b
1

Allergen immunotherapy

X.e X.f
2

Allopurinol

VI.d X.a X.m X.n
1

Almitrine

XI.d
1

Alteplase (rTPA)

III.a V.e VIII.a
1
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Note Legend
?

  • -
    Questionable signal
  • 1
    < 10 cases
  • 2
    10 - 50 cases
  • 3
    50 - 100 cases
  • 4
    100 - 200 cases
  • 5
    >200 cases

Legend Patterns
?

    • I -
      Parenchymal lung disease
      • I.a Acute ILD
      • I.b Subacute ILD
      • I.c Eosinophilic pneumonia (PIE)
      • I.d Organizing pneumonia (OP)
      • I.e Acute eosinophilic pneumonia (AEP)
      • I.f Acute fibrinous organizing pneumonia (AFOP)
      • I.g Pulmonary fibrosis
      • I.h Subclinical ILD
      • I.i Diffuse pulmonary calcification
      • I.j Exogenous lipoid pneumonia
      • I.k Lung nodule or nodules
      • I.l Diffuse alveolar damage (DAD)
      • I.m ILD with a granulomatous component
      • I.n Pulmonary alveolar proteinosis (PAP)
      • I.o Localized pulmonary fibrosis
      • I.p Interstitial foreign body reaction/granulomas
      • I.q Pulmonary nodulosis
      • I.r Endogenous lipoid pneumonia (phospholipidosis)
      • I.s A mass or masses
      • I.t Pneumoconiosis-talcosis
      • I.u 'Recall' radiation pneumonitis
      • I.v Subclinical changes in PFTs
      • I.w Rapidly progressive pulmonary fibrosis
      • I.x Biapical fibrosis
      • I.y Exacerbation of preexisting ILD or fibrosis
      • I.z Areas of consolidation
      • I.aa Deterioration of pulmonary LAMM
      • I.ab Radiation-induced lung injury (RILI)
      • I.ac Relapsing pneumonitis
    • II -
      Pulmonary edema - ALI - ARDS
      • II.a Noncardiogenic pulmonary edema - NCPE
      • II.b ALI - ARDS
      • II.c ARDS and the hemolytic-uremic syndrome
      • II.d Cardiogenic pulmonary edema
      • II.e Transfusion-related ALI (TRALI)
      • II.f Isolated hypoxemia/arterial desaturation
      • II.g Negative pressure pulmonary edema
      • II.h Overload pulmonary edema
      • II.i Flash pulmonary edema
      • II.j Transient pulmonary opacities
      • II.k The ATRA syndrome
    • III -
      Pulmonary hemorrhage
      • III.a Diffuse alveolar hemorrhage - DAH
      • III.b Pneumorenal syndrome
      • III.c Hemoptysis
      • III.d ANCA-associated DAH
      • III.e Pulmonary hematoma
    • IV -
      Airway involvement
      • IV.a Bronchospasm - wheezing - asthma
      • IV.b Bronchospasm and angioedema
      • IV.c Obliterative bronchiolitis
      • IV.d Lone cough
      • IV.e Acute violent coughing
      • IV.f Severe or catastrophic bronchospasm
      • IV.g Respiratory bronchiolitis ILD (RB-ILD)
      • IV.h Tracheobronchial necrosis
      • IV.i Foreign body bronchiolitis - Diffuse aspiration bronchiolitis
      • IV.j Calcification of cartilaginous rings
      • IV.k Bronchiectasis
      • IV.l Bronchial stump dehiscence
      • IV.m Bronchial stricture/stenosis
      • IV.n Obstructive airway dysfunction
      • IV.o Airway hyperresponsiveness
      • IV.p Thermal, chemical or caustic airway injury
      • IV.q Reactive airway dysfunction syndrome (RADS)
    • V -
      Pleural and/or pericardial involvement
      • V.a Pleural effusion, lone
      • V.b Eosinophilic pleuritis/effusion
      • V.c Pleural thickening/fibrosis
      • V.d Pleural and/or pericardial effusion and the lupus syndrome
      • V.e Serosanguineous effusion - Hemothorax
      • V.f Pneumothorax
      • V.g The ovarian hyperstimulation syndrome (OHSS)
      • V.h Chylothorax
      • V.i Acute pleuropulmonary reaction
      • V.j Subpleural fat deposits
      • V.k Pleural calcifications
      • V.l Malignant mesothelioma
      • V.m Pleuro-pericardial effusion
      • V.n Bloody pericardial effusion - Hemopericardium
      • V.o Acute pleuric chest pain
      • V.p Pleuroparenchymal fibroelastosis
      • V.q Empyema
      • V.r Pleural mass or masses
      • V.s Polyserositis
    • VI -
      Pulmonary vasculopathy
      • VI.a Pulmonary thromboembolism
      • VI.b Pulmonary arterial hypertension
      • VI.c Pulmonary veno-occlusive disease
      • VI.d Pulmonary vasculitis/capillaritis
      • VI.e Lipid/fat embolism
      • VI.f The hemolytic-uremic syndrome
      • VI.g Foreign body pulmonary vasculopathy
      • VI.h Acrylic cement embolism
      • VI.i Acute pulmonary hypertension
      • VI.j Mercury embolism
      • VI.k Eosinophilic pulmonary vasculitis
      • VI.l Acute pulmonary vasoconstriction and consequent PHTn
      • VI.m Silicone pulmonary embolism
      • VI.n Crystal pulmonary embolism
      • VI.o Air embolism (right-sided)
      • VI.p Angiomatoid pulmonary vasculopathy
      • VI.q Rebound pulmonary hypertension
      • VI.r Septic pulmonary emboli
      • VI.t Pulmonary artery aneurysm
      • VI.u Pulmonary microthrombi
      • VI.v Foreign body embolism
    • VII -
      Mediastinal involvement
      • VII.a Lymphadenopathy
      • VII.b Lymphadenopathy with reactive changes
      • VII.c Mediastinal lipomatosis
      • VII.d Fibrosing mediastinitis
      • VII.e Granulomatous lymphadenopathy
      • VII.f Enlarged thymus
      • VII.g Mediastinal bleeding/hemorrhage
      • VII.h Pneumomediastinum
      • VII.i Mediastinitis
      • VII.j Compression of mediastinal organs
      • VII.k Mediastinal infiltration
    • VIII -
      Central/large airway involvement/closure
      • VIII.a Angioedema
      • VIII.b Airway hematoma causing UAO
      • VIII.c UAO other than angioedema or hematoma
      • VIII.d Thermal, chemical or caustic airway injury
      • VIII.e Laryngospasm
      • VIII.f Central airway instability/malacia
      • VIII.g Tracheal narrowing - Sabre sheath trachea
      • VIII.h Vocal cord dysfunction, adduction or closure
      • VIII.i Midline destructive lesions
      • VIII.j Dysphonia
      • VIII.k Airway fire/explosion
      • VIII.k Submucosal tracheal bleeding
      • VIII.m Drug-associated airway foreign body
      • VIII.o Perforation of the nasal septum
      • VIII.q Tongue involvement
    • IX -
      Neuromuscular involvement
      • IX.a Respiratory muscle weakness or paralysis
      • IX.b Respiratory dyskinesia
      • IX.c Chest wall/muscle rigidity
      • IX.d Ventilatory depression - Apnea
      • IX.e Disordered breathing during sleep
      • IX.f Hiccup
      • IX.g Myopathy of respiratory muscles
      • IX.h Isolated dyspnea
    • X -
      Systemic reactions or conditions
      • X.a DRESS
      • X.b Antiphospholipid antibody syndrome (APLS)
      • X.c Vascular/capillary leak syndrome
      • X.d Drug-induced lupus
      • X.e Autoimmunity
      • X.f Anaphylaxis
      • X.g Hypersensitivity reaction
      • X.h Eosinophilic granulomatosis with polyangiitis (Churg-Strauss)
      • X.i Immune reconstitution syndrome - IRS/IRCS
      • X.j Myopathy - Myositis
      • X.k Sarcoid-like disease
      • X.l Subclinical ANA
      • X.m Systemic vasculitis
      • X.n Tumor lysis syndrome
      • X.o Sweet syndrome
      • X.p Serum sickness-like reaction
      • X.q Systemic inflammatory response
      • X.r Fluid retention
      • X.s ANCA-related disease or vasculitis
      • X.t Jarisch-Herxheimer reaction
      • X.u MOF/MODS
      • X.v Systemic eosinophilic syndrome
    • XI -
      Miscellaneous
      • XI.a Cyanosis, low SpO2 and a normal measured PaO2
      • XI.b Acute non-pleuritic chest pain/tightness/pressure
      • XI.c Acute pleuritic chest pain
      • XI.d Metabolic acidosis
      • XI.e Opportunistic pulmonary infection
      • XI.f Opportunistic airway infection
      • XI.g Aspiration pneumonia
      • XI.h Addictive risk
      • XI.i Isolated hypercapnea
      • XI.j Vertebral compression fracture
      • XI.k Rib hypertrophy, periostitis
      • XI.l Pharmacobezoar
      • XI.m Pulmonary emphysema - Lung bullae
      • XI.n Neutropenia - Agranulocytosis
      • XI.o Cavitary pulmonary opacities
      • XI.p Pneumocystis jiroveci pneumonia
      • XI.q Pneumocystis jiroveci colonization
      • XI.r Death from inhalation of compound
      • XI.s Tumoral cavitation
      • XI.t Lung abscess or abscesses
      • XI.u Pseudocyanotic skin discoloration
      • XI.v Mycobacterial (M tuberculosis-NTM-BCG) intrathoracic disease
      • XI.w Chest deformity - Platythorax
      • XI.x Lung compression from ascites
      • XI.y Death from overdose
      • XI.z Cutaneous vasculopathy (occlusive or vasculitic)
      • XI.aa Fire-eater's lung
      • XI.ab Yellow nail syndrome
      • XI.ac Chronic chest or musculoskeletal pain
      • XI.ad Rib fracture
      • XI.ae Esophageal tear/rupture: Boerhaave syndrome
      • XI.af Esophageal ulceration/stenosis/stricture
      • XI.ag Localized chest pain
      • XI.ah Superior vena cava syndrome
    • XII -
      Heart/circulatory involvement
      • XII.a Left ventricular failure
      • XII.b Valvular heart disease
      • XII.c Pericardial effusion or tamponade
      • XII.d Myocarditis
      • XII.e Tako-tsubo cardiomyopathy
      • XII.f Cardiomyopathy
      • XII.g Acute coronary syndrome - Myocardial infarction
      • XII.h Eosinophilic myocarditis
      • XII.i Endocarditis
      • XII.j Myocardial stunning
      • XII.k Pericardial thickening/constriction
      • XII.l Arrhythmias - Dysrhythmias
      • XII.m Cardiopulmonary arrest
      • XII.n Hypotension, cardiovascular collapse, shock
      • XII.o Coronary artery disease
      • XII.p Long QT syndrome
      • XII.r Coarctation of the aorta (acquired)
      • XII.r Congestive heart failure
      • XII.s Heart block
      • XII.t 'Torsades de pointe'
      • XII.u Left atrial/ventricular thrombosis
      • XII.v Arterial hypotension
      • XII.w Hypertrophic cardiomyopathy
    • XIII -
      Neoplasias - Neoplasms
      • XIII.a Solid tumors including lung cancer
      • XIII.b Lymphoproliferative disease
      • XIII.c Leukemia
      • XIII.d Malignant mesothelioma
    • XIV -
      Hemoglobinopathies, acquired
      • XIV.a Methemoglobinemia
      • XIV.b Sulfhemoglobinemia
      • XIV.c Carboxyhemoglobinemia
      • XIV.d Interference with COHb measurement
      • XIV.e Interference with SpO2 measurement
    • XV -
      Pathology
      • XV.a Path: Cellular ILD - NSIP-pattern
      • XV.b Path: Eosinophilic pneumonia (subacute or acute)
      • XV.c Path: Organizing pneumonia pattern
      • XV.d Path: Acute fibrinous organizing pneumonia, AFOP-pattern
      • XV.e Path: ILD with a granulomatous component
      • XV.f Path: Diffuse alveolar damage (DAD) - Hyaline membranes
      • XV.g Path: Diffuse alveolar hemorrhage (DAH)
      • XV.h Path: Pulmonary fibrosis (NSIP/fibrotic-pattern)
      • XV.i Path: A reactive alveolar or bronchiolar epithelium
      • XV.j Path: UIP-pattern
      • XV.k Path: DIP-pattern
      • XV.l Path: GIP-pattern
      • XV.m Path: Lymphoid hyperplasia, LIP-pattern
      • XV.n Path: PAP-pattern - secondary PAP
      • XV.o Path: Endogenous lipoid pneumonia - phospholipidosis
      • XV.p Path: Exogenous lipoid pneumonia
      • XV.q Path: Interstitial foreign body deposits/reaction
      • XV.r Path: Smudged geographic necrosis
      • XV.s Path: Pneumoconiosis, talcosis, talcoma
      • XV.t Path: Pulmonary amyloid deposits
      • XV.u Path: Crystal storage disease
      • XV.u Path: Diffuse pulmonary calcification
      • XV.u Path: Pulmonary edema
      • XV.v Path: Subacute/acute cellular bronchiolitis
      • XV.w Path: RB-ILD
      • XV.x Path: Obliterative broncholitis
      • XV.y Path: Foreign body bronchiolitis
      • XV.z Path: Pulmonary capillaritis
      • XV.aa Path: Pulmonary vasculitis other than capillaritis
      • XV.ab Path: Eosinophilic vasculitis
      • XV.ac Path: Fat embolism
      • XV.ad Path: Silicone embolism/deposits
      • XV.ae Path: Foreign body microangiopathy/vasculopathy
      • XV.af Path: Elemental mercury embolism
      • XV.ag Path: Cement embolism
      • XV.ah Path: Crystal pulmonary embolism
      • XV.ai Path: Venoocclusive disease (PVOD)
      • XV.aj Path: Pulmonary hypertension incl. angiomatoid vasculopathy
      • XV.ak Path: Pleuritis n.o.s.
      • XV.al Path: Eosinophilic pleuritis
      • XV.am Path: Pleural fibrosis
      • XV.an Path: Pleuroparenchymal fibroelastosis
      • XV.ao Path: Kayexalate lung
      • XV.ap Path: Alveolar carbonaceous deposits
      • XV.aq Path: Fire eater's lung
      • XV.ar Path: Pulmonary microvascular granulocyte sequestration
      • XV.as Path: Deterioration of pulmonary LAMM
      • XV.at Path: Textiloma - Gossypiboma
      • XV.au Path: Occlusive skin vasculopathy
      • XV.av Path: Siliconoma
      • XV.aw Path: Smoking-related interstitial fibrosis (SRIF)
      • XV.ax Path: Lymphadenopathy with reactive changes
      • XV.ay Path: Granulomatous lymphadenopathy
      • XV.az Path: Eosinophilic bronchiolitis
      • XV.ba Path: Opportunistic pulmonary infection
      • XV.bb Path: Bronchiolar vasculitis and necrosis
      • XV.bc Path: Interstitial pulmonary edema
      • XV.bd Path: Pulmonary necrotizing granulomas
      • XV.be Path: Tracheal or bronchial wall ulceration
      • XV.bf Path: Foreign body reaction in large airway wall
    • XVI -
      Imaging
      • XVI.a Imaging: Diffuse haze
      • XVI.b Imaging: Ground-glass opacities (GGO)
      • XVI.c Imaging: Mosaic pattern of attenuation
      • XVI.d Imaging: Batwing or butterfly pattern
      • XVI.e Imaging: Subpleural pulmonary opacities
      • XVI.f Imaging: Bibasilar opacities
      • XVI.g Imaging: Diffuse whiteout
      • XVI.h Imaging: Biapical or mid-lung opacities
      • XVI.i Imaging: Areas of involvement with a recognizable anatomic distribution
      • XVI.j Imaging: Wandering pulmonary opacities
      • XVI.k Imaging: Areas of consolidation
      • XVI.l Imaging: Peribronchovascular consolidation
      • XVI.m Imaging: Interlobular septal thickening
      • XVI.n Imaging: Intralobular septal thickening - Crazy paving
      • XVI.o Imaging: Localized ground-glass
      • XVI.p Imaging: Reticulation
      • XVI.q Imaging: An IPF-like imaging pattern
      • XVI.r Imaging: Areas of involvement with low attenuation numbers
      • XVI.s Imaging: Areas of involvement with high attenuation numbers
      • XVI.u Imaging: Diffuse random micronodules
      • XVI.v Imaging: Diffuse centrilobular micronodules
      • XVI.w Imaging: Multiple lung nodules
      • XVI.x Imaging: Halo sign
      • XVI.y Imaging: Reversed halo (Atoll) sign
      • XVI.z Imaging: A large nodule, nodules or masses
      • XVI.aa Imaging: Nodules, mass or masses with a central area of low attenuation
      • XVI.ab Imaging: Cavitary lung nodules
      • XVI.ac Imaging: XXX
      • XVI.ad Imaging: A calcified mass or masses
      • XVI.ae Imaging: Progressive massive fibrosis (PMF)
      • XVI.af Imaging: Lung bullae or cysts
      • XVI.ag Imaging: Pulmonary emphysema
      • XVI.ah Imaging: Pneumatoceles
      • XVI.ai Imaging: A tree-in-bud pattern
      • XVI.aj Imaging: Bronchiectasis
      • XVI.ak Imaging: Calcification of cartilaginous rings
      • XVI.al Imaging: Bronchial wall thickening
      • XVI.am Imaging: XXX
      • XVI.an Imaging: Pleural effusion
      • XVI.ao Imaging: Massive pleural effusion
      • XVI.ap Imaging: Pleural thickening
      • XVI.aq Imaging: Pneumothorax
      • XVI.ar Imaging: Hydropneumothorax
      • XVI.as Imaging: Pleural mass or masses
      • XVI.at Imaging:
      • XVI.au Imaging:
      • XVI.av Imaging:
      • XVI.aw Imaging:
      • XVI.ax Imaging: Vasc
      • XVI.ay Imaging: Vasc
      • XVI.az Imaging: Vasc
      • XVI.ba Imaging:
      • XVI.bb Imaging: Pneumomediastinum
      • XVI.bc Imaging: Lymph node enlargement
      • XVI.bd Imaging:
      • XVI.be Imaging: Enlarged thoracic venous collaterals
    • XVII -
      Infection
      • XVII.a Pneumonia n.o.s.
      • XVII.b Bacterial pneumonia
      • XVII.c Pulmonary aspergillosis
      • XVII.d Pneumocystis jiroveci colonization
      • XVII.e Pneumocystis jiroveci pneumonia
      • XVII.f Viral pneumonia
      • XVII.g Tuberculosis
      • XVII.h Pulmonary NTM infection
      • XVII.i BCG infection
      • XVII.j Pulmonary mucormycosis
      • XVII.k Bacterial colonization of the airways
      • XVII.l Fungal colonization of the airways
      • XVII.m Pseudomembranous Aspergillus tracheobronchitis
    • XVIII -
      Distinctive signs and/or symptoms: eye catchers
      • XVIII.a x
      • XVIII.b x
      • XVIII.c x
      • XVIII.d x
      • XVIII.e x
      • XVIII.f x
      • XVIII.g x
      • XVIII.h x
      • XVIII.j x
      • XVIII.k Eye-catcher: Multiple radiolucent balls
      • XVIII.l Eye-catcher: Tongue edema
      • XVIII.m Eye-catcher: Acrylic cement embolism
      • XVIII.n Eye-catcher: Lipiodol pulmonary embolism
    • XIX -
      Cytology (BAL, pleural fluid, FNA) - BAL fluid
      • XIX.a Cytology: Lymphocytic BAL
      • XIX.b Cytology: Neutrophilic BAL
      • XIX.c Cytology: Eosinophilic BAL
      • XIX.d Cytology: Hemorrhagic BAL
      • XIX.e Cytology: Stainable iron-laden macrophages in BALF
      • XIX.f Cytology: Foamy (phospholipidotic) macrophages (BALF, pleural fluid, FNA)
      • XIX.g Cytology: Atypical alveolar cells in BALF
      • XIX.h -
      • XIX.i Cytology: Multinucleated giant cells in BALF
      • XIX.j Free mineral oil in BALF
      • XIX.k Cytology: Talc crystals in macrophages or lying freely in BALF
    • XX -
      Diagnostic criteria for DIRD

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