The Drug-Induced Respiratory Disease Website
Philippe Camus 2012- v2
Pascal Foucher - Philippe Camus 1997- v1
Department of Pulmonary Medicine and Intensive Care University Hospital Dijon France
Contribution: Ph Bonniaud, N Baudouin, A Fanton, C Camus, N Favrolt, M Guerriaud, L Jacquet
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Note Legend ?
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-Questionable signal
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1< 10 cases
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210 - 50 cases
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350 - 100 cases
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4100 - 200 cases
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5>200 cases
Legend Patterns ?
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I -
Parenchymal lung disease
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- I.a Acute ILD
- I.b Subacute ILD
- I.c Eosinophilic pneumonia (PIE)
- I.d Organizing pneumonia (OP)
- I.e Acute eosinophilic pneumonia (AEP)
- I.f Acute fibrinous organizing pneumonia (AFOP)
- I.g Pulmonary fibrosis
- I.h Subclinical ILD
- I.i Diffuse pulmonary calcification
- I.j Exogenous lipoid pneumonia
- I.k Lung nodule or nodules
- I.l Diffuse alveolar damage (DAD)
- I.m ILD with a granulomatous component
- I.n Pulmonary alveolar proteinosis (PAP)
- I.o Localized pulmonary fibrosis
- I.p Interstitial foreign body reaction/granulomas
- I.q Pulmonary nodulosis
- I.r Endogenous lipoid pneumonia (phospholipidosis)
- I.s A mass or masses
- I.t Pneumoconiosis-talcosis
- I.u 'Recall' radiation pneumonitis
- I.v Subclinical changes in PFTs
- I.w Rapidly progressive pulmonary fibrosis
- I.x Biapical fibrosis
- I.y Progression or exacerbation of preexisting ILD or fibrosis
- I.z Areas of consolidation
- I.aa Deterioration of pulmonary LAMM
- I.ab Radiation-induced lung injury (RILI)
- I.ac Relapsing pneumonitis
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I -
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II -
Pulmonary edema - ALI - ARDS
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- II.a Noncardiogenic pulmonary edema - NCPE
- II.b ALI - ARDS
- II.c ARDS and the hemolytic-uremic syndrome
- II.d Cardiogenic pulmonary edema
- II.e Transfusion-related ALI (TRALI)
- II.f Isolated hypoxemia/arterial desaturation
- II.g Negative pressure pulmonary edema
- II.h Overload pulmonary edema
- II.i Flash pulmonary edema
- II.j Transient pulmonary opacities
- II.k The ATRA syndrome
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II -
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III -
Pulmonary hemorrhage
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- III.a Diffuse alveolar hemorrhage - DAH
- III.b Pneumorenal syndrome
- III.c Hemoptysis
- III.d ANCA-associated DAH
- III.e Pulmonary hematoma
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III -
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IV -
Airway involvement
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- IV.a Bronchospasm - wheezing - asthma
- IV.b Bronchospasm and angioedema
- IV.c Obliterative bronchiolitis
- IV.d Lone isolated cough
- IV.e Acute violent coughing
- IV.f Severe or catastrophic bronchospasm
- IV.g Respiratory bronchiolitis ILD (RB-ILD)
- IV.h Tracheobronchial necrosis
- IV.i Foreign body bronchiolitis - Diffuse aspiration bronchiolitis
- IV.j Calcification of cartilaginous rings
- IV.k Bronchiectasis
- IV.l Bronchial stump dehiscence
- IV.m Bronchial stricture/stenosis
- IV.n Obstructive airway dysfunction
- IV.o Airway hyperresponsiveness
- IV.p Thermal, chemical or caustic airway injury
- IV.q Reactive airway dysfunction syndrome (RADS)
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IV -
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V -
Pleural and/or pericardial involvement
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- V.a Pleural effusion
- V.b Eosinophilic pleural effusion
- V.c Pleural thickening/fibrosis
- V.d Drug-induced lupus with pleural/pericardial effusion
- V.e Serosanguineous pleural effusion - Hemothorax
- V.f Pneumothorax
- V.g Effusions and the ovarian hyperstimulation syndrome (OHSS)
- V.h Chylothorax
- V.i Acute pleuropulmonary reaction
- V.j Subpleural fat deposits
- V.k Pleural calcifications
- V.l Malignant mesothelioma
- V.m Pleuro-pericardial effusion (ANA-negative)
- V.n Bloody pericardial effusion - Hemopericardium
- V.o Acute pleuric chest pain
- V.p Pleuroparenchymal fibroelastosis
- V.q Empyema
- V.r Pleural mass or masses
- V.s Polyserositis
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V -
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VI -
Pulmonary vasculopathy
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- VI.a Pulmonary thromboembolism
- VI.b Pulmonary arterial hypertension
- VI.c Pulmonary veno-occlusive disease
- VI.d Pulmonary vasculitis or capillaritis (w/wo ANCA)
- VI.e Lipid/fat pulmonary embolism
- VI.f The hemolytic-uremic syndrome
- VI.g Foreign body pulmonary vasculopathy
- VI.h Acrylic cement pulmonary embolism
- VI.i Acute pulmonary hypertension
- VI.j Mercury pulmonary embolism
- VI.k Eosinophilic pulmonary vasculitis
- VI.l Acute pulmonary vasoconstriction and consequent PHTn
- VI.m Silicone pulmonary embolism
- VI.n Crystal pulmonary embolism
- VI.o Air embolism (RV - pulmonary circulation)
- VI.p Angiomatoid pulmonary vasculopathy
- VI.q Rebound pulmonary hypertension
- VI.r Septic pulmonary emboli
- VI.t Pulmonary artery aneurysm
- VI.u Pulmonary microthrombi
- VI.v Foreign body pulmonary embolism
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VI -
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VII -
Mediastinal involvement
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- VII.a Lymphadenopathy
- VII.b Lymphadenopathy with reactive changes
- VII.c Mediastinal lipomatosis
- VII.d Fibrosing mediastinitis
- VII.e Granulomatous lymphadenopathy
- VII.f Enlarged thymus
- VII.g Mediastinal bleeding/hemorrhage
- VII.h Pneumomediastinum
- VII.i Mediastinitis
- VII.j Compression of mediastinal organs
- VII.k Mediastinal infiltration
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VII -
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VIII -
Central/large airway involvement and/or closure
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- VIII.a Upper airway angioedema
- VIII.b Airway hematoma
- VIII.c UAO other than angioedema or hematoma
- VIII.d Thermal, chemical or caustic airway injury
- VIII.e Laryngospasm
- VIII.f Central airway instability/malacia
- VIII.g Tracheal narrowing - Sabre sheath trachea
- VIII.h Vocal cord dysfunction, adduction or closure
- VIII.i Midline facial destructive lesions
- VIII.j Dysphonia
- VIII.k Airway fire/explosion
- VIII.k Submucosal tracheal bleeding
- VIII.m Drug-associated airway foreign body
- VIII.o Perforation of the nasal septum
- VIII.q Acute tongue involvement
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VIII -
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IX -
Neuromuscular involvement
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- IX.a Respiratory muscle weakness or paralysis
- IX.b Respiratory dyskinesia
- IX.c Chest wall/muscle rigidity
- IX.d Ventilatory depression - Apnea
- IX.e Disordered breathing during sleep
- IX.f Hiccup
- IX.g Myopathy of respiratory muscles
- IX.h Isolated dyspnea
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IX -
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X -
Systemic reactions or conditions
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- X.a DRESS
- X.b Antiphospholipid antibody syndrome
- X.c Vascular/capillary leak syndrome
- X.d Drug-induced lupus syndrome
- X.e Autoimmunity
- X.f Anaphylaxis
- X.g Hypersensitivity reactions
- X.h Eosinophilic granulomatosis with polyangiitis (Churg-Strauss)
- X.i Immune reconstitution syndrome - IRS/IRCS
- X.j Myopathy - Myositis
- X.k Sarcoid-like disease
- X.l Subclinical ANA
- X.m Systemic vasculitis
- X.n Tumor lysis syndrome
- X.o Sweet syndrome
- X.p Serum sickness-like reaction
- X.q Systemic inflammatory response
- X.r Fluid retention
- X.s ANCA-related systemic disease/vasculitis
- X.t Jarisch-Herxheimer reaction
- X.u MOF/MODS
- X.v Systemic eosinophilic syndrome
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X -
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XI -
Miscellaneous
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- XI.a Cyanosis, low SpO2 and a normal measured PaO2
- XI.b Acute non-pleuritic chest pain/tightness/pressure
- XI.c Acute pleuritic chest pain
- XI.d Metabolic acidosis
- XI.e Opportunistic pulmonary infection
- XI.f Opportunistic airway infection
- XI.g Aspiration pneumonia
- XI.h Addictive risk
- XI.i Isolated hypercapnea
- XI.j Vertebral compression fracture
- XI.k Rib hypertrophy, periostitis
- XI.l Pharmacobezoar
- XI.m Pulmonary emphysema - Lung bullae
- XI.n Neutropenia - Agranulocytosis
- XI.o Cavitary pulmonary opacities
- XI.p Pneumocystis jiroveci pneumonia
- XI.q Pneumocystis jiroveci colonization
- XI.r Death from inhalation of compound
- XI.s Tumoral cavitation
- XI.t Lung abscess or abscesses
- XI.u Pseudocyanotic skin discoloration
- XI.v Mycobacterial (M tuberculosis-NTM-BCG) intrathoracic disease
- XI.w Chest deformity - Platythorax
- XI.x Lung compression from ascites
- XI.y Death from overdose
- XI.z Cutaneous vasculopathy (occlusive or vasculitic)
- XI.aa Basilar consolidation of the 'Fire-eater's lung'
- XI.ab Yellow nail syndrome
- XI.ac Chronic chest or musculoskeletal pain
- XI.ad Rib fracture
- XI.ae Esophageal tear/rupture: Boerhaave syndrome
- XI.af Esophageal ulceration/stenosis/stricture
- XI.ag Localized chest pain
- XI.ah Superior vena cava syndrome
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XI -
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XII -
Heart/circulatory involvement
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- XII.a Left ventricular failure
- XII.b Valvular heart disease
- XII.c Pericardial effusion or tamponade
- XII.d Myocarditis
- XII.e Tako-tsubo cardiomyopathy
- XII.f Cardiomyopathy
- XII.g Acute coronary syndrome - Myocardial infarction
- XII.h Eosinophilic myocarditis
- XII.i Endocarditis
- XII.j Myocardial stunning
- XII.k Pericardial thickening/constriction
- XII.l Arrhythmias - Dysrhythmias
- XII.m Cardiopulmonary arrest
- XII.n Hypotension, cardiovascular collapse, shock
- XII.o Coronary artery disease
- XII.p Long QT syndrome
- XII.r Coarctation of the aorta (acquired)
- XII.r Congestive heart failure
- XII.s Heart block
- XII.t 'Torsades de pointe'
- XII.u Left atrial/ventricular thrombosis
- XII.v Arterial hypotension
- XII.w Hypertrophic cardiomyopathy
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XII -
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XIII -
Thoracic cancers and neoplasms
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- XIII.a Lung cancer and other thoracic tumors
- XIII.b Lymphoproliferative chest disease
- XIII.c Leukemia
- XIII.d Malignant mesothelioma
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XIII -
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XIV -
Hemoglobinopathy (acquired)
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- XIV.a Methemoglobinemia
- XIV.b Sulfhemoglobinemia
- XIV.c Carboxyhemoglobinemia
- XIV.d Interference with COHb measurement
- XIV.e Interference with SpO2 measurement
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XIV -
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XV -
Pathology
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- XV.a Path: Cellular ILD - NSIP-cellular
- XV.b Path: Eosinophilic pneumonia (subacute or acute)
- XV.c Path: Organizing pneumonia-pattern
- XV.d Path: Acute fibrinous organizing pneumonia, AFOP-pattern
- XV.e Path: ILD with a granulomatous component
- XV.f Path: Diffuse alveolar damage (DAD) - Hyaline membranes
- XV.g Path: Diffuse alveolar hemorrhage (DAH)
- XV.h Path: Pulmonary fibrosis (NSIP-fibrotic)
- XV.i Path: A reactive alveolar or bronchiolar epithelium
- XV.j Path: UIP-pattern
- XV.k Path: DIP-pattern
- XV.l Path: Unclassifiable pulmonary fibrosis
- XV.m Path: Lymphoid hyperplasia, LIP-pattern
- XV.n Path: PAP-pattern - secondary PAP
- XV.o Path: Endogenous lipoid pneumonia: phospholipidosis
- XV.p Path: Exogenous lipoid pneumonia
- XV.q Path: Interstitial foreign body reaction and deposits
- XV.r Path: Smudged geographic necrosis
- XV.s Path: Pneumoconiosis, talcosis, talcoma
- XV.t Path: Pulmonary amyloid deposits
- XV.u Path: Crystal storage disease
- XV.u Path: Diffuse pulmonary calcification
- XV.u Path: Pulmonary edema
- XV.v Path: Subacute/acute cellular bronchiolitis
- XV.w Path: Respiratory bronchiolitis (RB-) ILD-pattern
- XV.x Path: Obliterative broncholitis
- XV.y Path: Foreign body bronchiolitis
- XV.z Path: Pulmonary capillaritis
- XV.aa Path: Pulmonary vasculitis other than capillaritis
- XV.ab Path: Eosinophilic vasculitis
- XV.ac Path: Fat embolism
- XV.ad Path: Silicone in lung tissue or capillaries
- XV.ae Path: Foreign body microangiopathy/vasculopathy
- XV.af Path: Elemental mercury embolism
- XV.ag Path: Cement embolism
- XV.ah Path: Crystal pulmonary embolism
- XV.ai Path: Venoocclusive disease (PVOD)
- XV.aj Path: Pulmonary hypertension incl. angiomatoid vasculopathy
- XV.ak Path: Pleuritis n.o.s.
- XV.al Path: Eosinophilic pleuritis
- XV.am Path: Pleural fibrosis
- XV.an Path: Pleuroparenchymal fibroelastosis
- XV.ao Path: Kayexalate lung
- XV.ap Path: Alveolar carbonaceous deposits
- XV.aq Path: Fire eater's lung
- XV.ar Path: Pulmonary microvascular granulocyte sequestration
- XV.as Path: Deterioration of pulmonary LAMM
- XV.at Path: Textiloma - Gossypiboma
- XV.au Path: Occlusive skin vasculopathy
- XV.av Path: Siliconoma
- XV.aw Path: Smoking-related interstitial fibrosis (SRIF)
- XV.ax Path: Lymphadenopathy with reactive changes
- XV.ay Path: Granulomatous lymphadenopathy
- XV.az Path: Eosinophilic bronchiolitis
- XV.ba Path: Opportunistic pulmonary infection
- XV.bb Path: Bronchiolar vasculitis and necrosis
- XV.bc Path: Interstitial pulmonary edema
- XV.bd Path: Pulmonary necrotizing granulomas
- XV.be Path: Tracheal or bronchial wall ulceration
- XV.bf Path: Foreign body reaction in large airway wall
- XV.bg Path: Giant-cell interstitial pneumonia (GIP)-pattern
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XV -
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XVI -
Imaging
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- XVI.a Imaging: Diffuse haze
- XVI.b Imaging: Ground-glass opacities (GGO)
- XVI.c Imaging: Mosaic pattern of attenuation
- XVI.d Imaging: Batwing or butterfly pattern
- XVI.e Imaging: Subpleural pulmonary opacities
- XVI.f Imaging: Bibasilar opacities
- XVI.g Imaging: Diffuse whiteout
- XVI.h Imaging: Biapical or mid-lung opacities
- XVI.i Imaging: An area or areas of involvement with a recognizable anatomic distribution
- XVI.j Imaging: Wandering pulmonary opacities
- XVI.k Imaging: An area or areas of consolidation
- XVI.l Imaging: Peribronchovascular consolidation
- XVI.m Imaging: Interlobular septal thickening
- XVI.n Imaging: Intralobular septal thickening - Crazy paving
- XVI.o Imaging: Localized ground-glass
- XVI.p Imaging: Reticulation
- XVI.q Imaging: An IPF-like imaging pattern
- XVI.r Imaging: Areas of involvement with low attenuation numbers
- XVI.s Imaging: Areas of involvement with high attenuation numbers
- XVI.u Imaging: Diffuse random micronodules
- XVI.v Imaging: Diffuse centrilobular micronodules
- XVI.w Imaging: Multiple lung nodules
- XVI.x Imaging: Halo sign
- XVI.y Imaging: Reversed halo (Atoll) sign
- XVI.z Imaging: A large nodule, nodules or masses
- XVI.aa Imaging: Nodules, mass or masses with a central area of low attenuation
- XVI.ab Imaging: Cavitary lung nodules
- XVI.ac Imaging: XXX
- XVI.ad Imaging: A calcified mass or masses
- XVI.ae Imaging: Progressive massive fibrosis (PMF)
- XVI.af Imaging: Lung bullae or cysts
- XVI.ag Imaging: Pulmonary emphysema
- XVI.ah Imaging: Pneumatoceles
- XVI.ai Imaging: A tree-in-bud pattern
- XVI.aj Imaging: Bronchiectasis
- XVI.ak Imaging: Calcification of cartilaginous rings
- XVI.al Imaging: Bronchial wall thickening
- XVI.am Imaging: XXX
- XVI.an Imaging: Pleural effusion
- XVI.ao Imaging: Massive pleural effusion
- XVI.ap Imaging: Pleural thickening
- XVI.aq Imaging: Pneumothorax
- XVI.ar Imaging: Hydropneumothorax
- XVI.as Imaging: Pleural mass or masses
- XVI.at Imaging:
- XVI.au Imaging:
- XVI.av Imaging:
- XVI.aw Imaging:
- XVI.ax Imaging: Vasc
- XVI.ay Imaging: Vasc
- XVI.az Imaging: Vasc
- XVI.ba Imaging:
- XVI.bb Imaging: Pneumomediastinum
- XVI.bc Imaging: Lymph node enlargement
- XVI.bd Imaging:
- XVI.be Imaging: Enlarged thoracic venous collaterals
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XVI -
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XVII -
Infection
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- XVII.a Pneumonia n.o.s.
- XVII.b Bacterial pneumonia
- XVII.c Pulmonary aspergillosis
- XVII.d Pneumocystis jiroveci colonization
- XVII.e Pneumocystis jiroveci pneumonia
- XVII.f Viral pneumonia
- XVII.g Tuberculosis
- XVII.h Pulmonary NTM infection
- XVII.i BCG infection
- XVII.j Pulmonary mucormycosis
- XVII.k Bacterial colonization of the airways
- XVII.l Fungal colonization of the airways
- XVII.m Pseudomembranous Aspergillus tracheobronchitis
- XVII.n Opportunistic pulmonary infections
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XVII -
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XVIII -
Distinctive signs and/or symptoms: eye catchers
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- XVIII.a x
- XVIII.b x
- XVIII.c x
- XVIII.d x
- XVIII.e x
- XVIII.f x
- XVIII.g x
- XVIII.h x
- XVIII.j x
- XVIII.k Eye-catcher: Multiple radiolucent balls
- XVIII.l Eye-catcher: Tongue edema
- XVIII.m Eye-catcher: Acrylic cement embolism
- XVIII.n Eye-catcher: Lipiodol pulmonary embolism
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XVIII -
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XIX -
Cytology (BAL, pleural fluid, FNA)
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- XIX.a Cytology: Lymphocytic BAL pattern
- XIX.b Cytology: Neutrophilic BAL pattern
- XIX.c Cytology: Eosinophilic BAL pattern
- XIX.d Cytology: Hemorrhagic BAL pattern
- XIX.e Cytology: Stainable iron-laden macrophages in BALF
- XIX.f Cytology: Foamy (phospholipidotic) macrophages (BALF, pleural fluid, FNA)
- XIX.g Cytology: Atypical alveolar cells in BALF
- XIX.h -
- XIX.i Cytology: Multinucleated giant cells in BALF
- XIX.j Free mineral oil in BALF
- XIX.k Cytology: Talc crystals in macrophages or lying freely in BALF
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XIX -
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