Pneumotox » Drug » Tacrolimus (FK506)

Tacrolimus (FK506)

1

Last update : 15/01/2017

I.a Pneumonitis (ILD), acute and/or severe (may cause ARDS)

1

I.b Pneumonitis (ILD)

1

I.d Organizing pneumonia pattern (an area or areas of consolidation on imaging)

1

I.e Acute eosinophilic pneumonia (AEP)

1

II.b ARDS - Acute lung injury

1

VI.f Hemolytic and uremic syndrome (HUS). See also under Xaf

1

X.af Thrombotic microangiopathy

1

XVII.b Opportunistic pulmonary/systemic infections

1

XVII.e Pneumocystis jiroveci pneumonia

1

Diagnosing DIRD

1

Drug and radiation history

2

Drug singularity - Correct identification of the drug

3

Consistent timing of exposure v. onset of symptoms

4

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

5

Careful exlusion of another cause

6

Remission of symptoms with removal of drug

7

Recurrence with rechallenge (rarely advisable)

8

Causality assessment

More detailed checklist