Pneumotox » Drug » Rituximab-CHOP regimen (R-CHOP)

Rituximab-CHOP regimen (R-CHOP)

See under specific drugs of the regimen, including the anti-CD20 Rituximab. Under this heading are cases where the responsibility of any of the drugs composing the R-CHOP could not be confidently sorted out

Last update : 02/10/2018

I.b Pneumonitis (ILD)

I.d Organizing pneumonia pattern (an area or areas of consolidation on imaging)

III.a Alveolar hemorrhage (AH), diffuse AH (DAH)

XV.a Path: NSIP-cellular pattern (see also Ia, Ib)

XVI.u Imaging: A miliary pattern (diffuse random micronodules)

XVII.g Tuberculosis (pulmonary, pulmonary, extrapulmonary or disseminated). Reactivation or de novo

Diagnosing DIRD

Drug and radiation history

Drug singularity - Correct identification of the drug

Consistent timing of exposure v. onset of symptoms

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

Careful exlusion of another cause

Remission of symptoms with removal of drug

Recurrence with rechallenge (rarely advisable)

Causality assessment

More detailed checklist

The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.