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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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PD-1/PD-L1-inhibitors or blocking agents/drugs

5

I.b Pneumonitis (ILD)

3
Last update : 18/10/2016
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Immune checkpoint inhibitors (ICI) - ICI combinatorial Rx
5
Nivolumab
5
Pembrolizumab
5
Pidilizumab
1

Publications

Pneumonitis in Patients Treated With Anti-Programmed Death-1/Programmed Death Ligand 1 Therapy.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2017 Mar;35;709-717 2017 Mar
PD-1 Inhibitor-Related Pneumonitis in Advanced Cancer Patients: Radiographic Patterns and Clinical Course.
Clinical cancer research : an official journal of the American Association for Cancer Research 2016 Dec 15;22;6051-6060 2016 Dec 15
Incidence of Programmed Cell Death 1 Inhibitor-Related Pneumonitis in Patients With Advanced Cancer: A Systematic Review and Meta-analysis.
JAMA oncology 2016 Dec 01;2;1607-1616 2016 Dec 01

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