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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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SGN-30

1

I.a Pneumonitis (ILD), acute and/or severe (may cause ARDS)

1
Last update : 05/02/2015
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist

Publications

Serious pulmonary toxicity in patients with Hodgkin's lymphoma with SGN-30, gemcitabine, vinorelbine, and liposomal doxorubicin is associated with an FcγRIIIa-158 V/F polymorphism.
Annals of oncology : official journal of the European Society for Medical Oncology 2010 Nov;21;2246-2254 2010 Nov

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