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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Loperamide

3

XII.m Cardiac- cardiorespiratory/pulmonary arrest

1
Last update : 12/01/2017
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist

Publications

Adverse event detection using the FDA post-marketing drug safety surveillance system: Cardiotoxicity associated with loperamide abuse and misuse.
Journal of the American Pharmacists Association : JAPhA 2017;57;S63-S67 2017

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