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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Disinfectants (humidifier disinfectants used in the home or occupational setting)

5

II.b ARDS - Acute lung injury

2
Last update : 28/09/2015
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist

Publications

Humidifier disinfectant and use characteristics associated with lung injury in Korea.
Indoor air 2019 Sep;29;735-747 2019 Sep
Two Cases of Chloromethylisothiazolinone and Methylisothiazolinone-associated Toxic Lung Injury.
Journal of Korean medical science 2018 Apr 16;33;e119 2018 Apr 16
Humidifier disinfectant-associated interstitial lung disease and the Ardystil syndrome.
American journal of respiratory and critical care medicine 2015 Jan 01;191;116-7 2015 Jan 01

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