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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Fotemustine

1

II.b ARDS - Acute lung injury

1
Last update : 16/08/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Bendamustine
1
Carmustine (BCNU)
3
Lomustine (CCNU)
3
Nitrosoureas (suffixes '-NU', '-mustine')
4

Publications

[New toxicity of fotemustine: diffuse interstitial lung disease].
Annales de dermatologie et de venereologie 2012 Apr;139;277-81 2012 Apr
Activity and unexpected lung toxicity of the sequential administration of two alkylating agents--dacarbazine and fotemustine--in patients with melanoma.
European journal of cancer (Oxford, England : 1990) 1993;29A;711-9 1993
Sequential administration of dacarbazine and fotemustine in patients with disseminated malignant melanoma--an effective combination with unexpected toxicity.
European journal of cancer (Oxford, England : 1990) 1992;28;447-50 1992

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