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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Antiviral therapy/agents (direct-acting) against hepatitis C virus

1

III.a Alveolar hemorrhage (AH), diffuse AH (DAH)

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Last update : 30/06/2018
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Dasabuvir
1
Ledipasvir
1
Ledipasvir/Sofosbuvir
1
Ombitasvir
1
Paritaprevir
1
Ritonavir
1
Simeprevir
1
Sofosbuvir
1

Publications

Treatment with sofosbuvir and ledipasvir without ribavirin for 12 weeks is highly effective for recurrent hepatitis C virus genotype 1b infection after living donor liver transplantation: a Japanese multicenter experience.
Journal of gastroenterology 2017 Aug;52;986-991 2017 Aug

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