Pneumotox » Drug » Crushed tablets -pills (deliberate i.v. injection of) » XV.q - Path: Foreign body deposits/granulomatous reaction

Crushed tablets -pills (deliberate i.v. injection of)

May involve distant organs beyond the lung, notably if PFO is present (PMID 30513554)

Last update : 28/07/2019

Diagnosing DIRD

Drug and radiation history

Drug singularity - Correct identification of the drug

Consistent timing of exposure v. onset of symptoms

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

Careful exlusion of another cause

Remission of symptoms with removal of drug

Recurrence with rechallenge (rarely advisable)

Causality assessment