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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Umbralisib

1

I.a Pneumonitis (ILD), acute and/or severe (may cause ARDS)

1
Last update : 26/02/2018
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
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Careful exlusion of another cause
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Remission of symptoms with removal of drug
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Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist

Publications

Umbralisib, a novel PI3Kδ and casein kinase-1ε inhibitor, in relapsed or refractory chronic lymphocytic leukaemia and lymphoma: an open-label, phase 1, dose-escalation, first-in-human study.
The Lancet. Oncology 2018 Apr;19;486-496 2018 Apr

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