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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Hydralazine

4

X.d Lupus - Lupus syndrome (see also Vd)

3
Last update : 21/08/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist

Publications

Overlapping drug-induced vasculitis, ANCA-associated vasculitis, and lupus nephritis caused by low-dose hydralazine.
International journal of rheumatic diseases 2023 Nov;26;2272-2277 2023 Nov
The Utility of Bronchoscopy in Hydralazine-Induced ANCA-Associated Vasculitis.
Case reports in pulmonology 2023;2023;1461011 2023
An intriguing case of anemia and renal failure.
Proceedings (Baylor University. Medical Center) 2019 Jan;32;78-79 2019 Jan
Successful use of rituximab for hydralazine-induced anti-neutrophil cytoplasmic antibodies-associated vasculitis.
Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia 2019;30;226-230 2019
Hydralazine-induced lupus erythematosis.
Journal of clinical hypertension (Greenwich, Conn.) 2012 Feb;14;133-136 2012 Feb
Hydralazine for essential hypertension.
The Cochrane database of systematic reviews 2011 Nov 09;;CD004934 2011 Nov 09
Drug-induced lupus erythematosus: incidence, management and prevention.
Drug safety 2011 May 01;34;357-74 2011 May 01
Do selected drugs increase the risk of lupus? A matched case-control study.
British journal of clinical pharmacology 2010 Oct;70;588-96 2010 Oct
Hydralazine-induced autoimmune disease: comparison to idiopathic lupus and ANCA-positive vasculitis.
Modern rheumatology 2009;19;338-47 2009
Fulminating hydralazine-induced lupus pneumonitis.
Arthritis and rheumatism 2006 Jun 15;55;501-6 2006 Jun 15
Hydralazine-induced lupus and vocal fold paralysis.
The Journal of laryngology and otology 1998 Sep;112;875-7 1998 Sep
Antigen specificity in hydralazine associated ANCA positive systemic vasculitis.
QJM : monthly journal of the Association of Physicians 1995 Nov;88;775-83 1995 Nov
Effect of acute cytomegalovirus infection on drug-induced SLE.
Postgraduate medical journal 1994 Oct;70;738-40 1994 Oct
Autoantibodies against neutrophil cytoplasm components in systemic lupus erythematosus and in hydralazine-induced lupus.
Clinical and experimental immunology 1990 Sep;81;380-3 1990 Sep
Laryngeal manifestations of drug induced lupus.
The Journal of rheumatology 1987 Apr;14;375-7 1987 Apr
Drug-induced lupus caused by very-low-dose hydralazine.
British journal of rheumatology 1986 May;25;225 1986 May
Hypocomplementemia in hydralazine-associated systemic lupus erythematosus.
The American journal of medicine 1978 Sep;65;553-6 1978 Sep
Late systemic complications of hydralazine (apresoline) therapy.
Journal of the American Medical Association 1955 Mar 12;157;894-9 1955 Mar 12
Studies on the control of hypertension by hyphex. II. Toxic reactions and side effects.
Circulation 1953 Dec;8;829-39 1953 Dec

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