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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Hydrochlorothiazide

3

XXI.a Rechallenge can lead to near-fatal or fatal relapse of AE/ILD

1
Last update : 03/01/2019
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist

Publications

Hydrochlorothiazide-induced systemic capillary leak.
The American journal of emergency medicine 2020 Jun;38;1299.e1-1299.e2 2020 Jun
[Severe and rare adverse reaction to hydrochlorothiazide].
Revista alergia Mexico (Tecamachalco, Puebla, Mexico : 1993) 2018;65;442-445 2018
Acute allergic interstitial pneumonitis induced by hydrochlorothiazide.
CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne 1991 Jul 01;145;28-34 1991 Jul 01

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