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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Infliximab

5

X.s Vasculitis, pulmonary (w/wo AH), extrapulmonary, systemic: ANCA-positive

2
Last update : 28/12/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Biosimilars
1
Infliximab biosimilar
1
TNF-alpha antagonists / inhibitors
5

Publications

Recurrent drug-induced ANCA vasculitis in a patient with Crohn's colitis treated with infliximab: a potential contraindication to immunosuppressive therapy.
The American surgeon 2012 Dec;78;1406-8 2012 Dec
C-ANCA positive systemic vasculitis in a patient with rheumatoid arthritis treated with infliximab.
Clinical rheumatology 2008 Feb;27;261-4 2008 Feb

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