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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Infliximab

5

XVII.g Tuberculosis (pulmonary, pulmonary, extrapulmonary or disseminated). Reactivation or de novo

5
Last update : 14/01/2014
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Biosimilars
1
Infliximab biosimilar
1
TNF-alpha antagonists / inhibitors
5

Publications

Ileocolonic tuberculosis clinically, endoscopically, and radiologically mimicking Crohn's disease: disseminated infection after treatment with infliximab.
Journal of Crohn's & colitis 2014 Jun;8;560-2 2014 Jun
Development of miliary tuberculosis under infliximab in a patient with spondyloarthritis and suspected Crohn's disease.
Zeitschrift fur Gastroenterologie 2013 Oct;51;1177-83 2013 Oct
Intestinal tuberculosis mimicking Crohn disease in infliximab-treated rheumatoid arthritis.
Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases 2012 Sep;18;324 2012 Sep
Disseminated tuberculosis in a Crohn's disease patient on anti-TNF alpha therapy despite chemoprophylaxis.
Gut 2008 Mar;57;425; author reply 425-6 2008 Mar
Pulmonary nodules in an infliximab-treated rheumatoid arthritis patient: a clinical pathology conference held by the Division of Rheumatology at Hospital for Special Surgery.
HSS journal : the musculoskeletal journal of Hospital for Special Surgery 2007 Feb;3;119-25 2007 Feb
Pulmonary infectious complications associated with anti-TNFalpha therapy (infliximab) for rheumatoid arthritis.
Internal medicine (Tokyo, Japan) 2006;45;685-8 2006
Tuberculosis infection in patients with rheumatoid arthritis and the effect of infliximab therapy.
Arthritis and rheumatism 2004 Feb;50;372-9 2004 Feb
Treatment of rheumatoid arthritis with tumor necrosis factor inhibitors may predispose to significant increase in tuberculosis risk: a multicenter active-surveillance report.
Arthritis and rheumatism 2003 Aug;48;2122-7 2003 Aug
Pulmonary miliary tuberculosis in a patient with anti-TNF-alpha treatment.
Scandinavian journal of rheumatology 2002;31;44-5 2002

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