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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Ketorolac

1

IV.a Bronchospasm - Wheezing - Asthma

1
Last update : 20/01/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
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See also under
Nonsteroidal anti-inflammatory drugs (NSAIDs)
5

Publications

Fatal adverse reaction to ketorolac tromethamine in asthmatic patient.
The American journal of forensic medicine and pathology 2008 Dec;29;358-63 2008 Dec
Analgesic-induced asthma caused by 2.0% ketoprofen adhesive agents, but not by 0.3% agents.
Internal medicine (Tokyo, Japan) 2001 Feb;40;124-6 2001 Feb
Ketorolac-precipitated asthma.
Southern medical journal 1994 Feb;87;282-3 1994 Feb
Ketorolac-induced bronchospasm in an aspirin-intolerant patient.
Anesthesia progress 1994;41;102-7 1994
Ketorolac-induced bronchospasm.
Anesthesia and analgesia 1993 Feb;76;417-9 1993 Feb

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