The Drug-Induced Respiratory Disease Website
Philippe Camus, M.D.
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Lidocaine (lignocaine, xylocaine)
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Drug and radiation history
Drug singularity - Correct identification of the drug
Consistent timing of exposure v. onset of symptoms
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
Careful exlusion of another cause
Remission of symptoms with removal of drug
Recurrence with rechallenge (rarely advisable)
More detailed checklist
See also under
Anesthetic agents (local, topical)
Lidocaine-induced methemoglobinemia: a clinical reminder.
[Methaemoglobinaemia in a child treated with Emla(®) cream: circumstances and consequences of overdose].
Risk of acquired methemoglobinemia with different topical anesthetics during endoscopic procedures.
Application of topical analgesia in triage: a potential for harm.
Benzocaine and lidocaine induced methemoglobinemia after bronchoscopy: a case report.
Severe methemoglobinemia from topical anesthetic spray: case report, discussion and qualitative systematic review.
Severe methemoglobinemia following dental extractions under lidocaine anesthesia.