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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Fam-trastuzumab deruxtecan-nxki

2

I.b Pneumonitis (ILD)

2
Last update : 06/05/2025
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist

Publications

FDA approval summary: fam-trastuzumab deruxtecan-nxki for unresectable or metastatic non-small cell lung cancer with activating HER2 mutations.
The oncologist 2024 Aug 05;29;667-671 2024 Aug 05
Drug-induced interstitial lung disease: a real-world pharmacovigilance study of the FDA Adverse Event Reporting System from 2004 to 2021.
Therapeutic advances in drug safety 2024;15;20420986231224227 2024

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