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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Amphotericin B (infusion)

3

XII.m Cardiac- cardiorespiratory/pulmonary arrest

1
Last update : 11/08/2021
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist

Publications

Asystolic cardiac arrest following liposomal amphotericin B infusion: anaphylaxis or compliment activation-related pseudoallergy?
Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology 2021 Jul 29;17;80 2021 Jul 29

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