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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Amphotericin B (infusion)

3

II.b ARDS - Acute lung injury

2
Last update : 06/07/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
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Publications

Safety and toxicity of amphotericin B in glucose 5% or intralipid 20% in neutropenic patients with pneumonia or fever of unknown origin: randomised study.
BMJ (Clinical research ed.) 1998 Aug 08;317;379-84 1998 Aug 08
Lethal pulmonary reactions associated with the combined use of amphotericin B and leukocyte transfusions.
The New England journal of medicine 1981 May 14;304;1185-9 1981 May 14

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