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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Methadone

5

IX.d Respiratory failure from ventilatory depression (due to neuromuscular blockade/paralysis)

3
Last update : 06/08/2012
 
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Drug and radiation history
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Drug singularity - Correct identification of the drug
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Consistent timing of exposure v. onset of symptoms
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Clinical, imaging, BAL, pathological pattern consistent with the specific drug
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Careful exlusion of another cause
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Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
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See also under
Methadone, inhaled
1
Opiates - Opioids - Opium
5

Publications

Therapeutic and recreational methadone cardiotoxicity.
Journal of forensic and legal medicine 2016 Apr;39;80-4 2016 Apr
Evaluation of poly-drug use in methadone-related fatalities using segmental hair analysis.
Forensic science international 2015 Mar;248;134-9 2015 Mar
Prognostic factors in acute methadone toxicity: a 5-year study.
Journal of toxicology 2014;2014;341826 2014
Methadone toxicity in a poisoning referral center.
Journal of research in pharmacy practice 2013 Jul;2;130-4 2013 Jul
Medical outcomes associated with nonmedical use of methadone and buprenorphine.
The Journal of emergency medicine 2013 Aug;45;199-205 2013 Aug
Effectiveness of naltrexone in the prevention of delayed respiratory arrest in opioid-naive methadone-intoxicated patients.
BioMed research international 2013;2013;903172 2013
An unusual case of accidental poisoning: fatal methadone inhalation.
Journal of forensic sciences 2011 Jul;56;1072-5 2011 Jul
Contributing factors to methadone-related deaths in Ontario.
The American journal of forensic medicine and pathology 2010 Dec;31;313-9 2010 Dec
Accidental methadone ingestion in an infant: case report and review of the literature.
Pediatric emergency care 2009 Feb;25;109-11 2009 Feb
Case report: quantification of methadone-induced respiratory depression using toxicokinetic/toxicodynamic relationships.
Critical care (London, England) 2007;11;R5 2007
Methadone-induced respiratory depression after discontinuing carbamazepine administration.
Journal of pain and symptom management 2006 Aug;32;99-100 2006 Aug

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