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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Methadone

5

IX.i Respiratory arrest - Apnea

2
Last update : 23/03/2015
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Methadone, inhaled
1
Opiates - Opioids - Opium
5

Publications

Therapeutic and recreational methadone cardiotoxicity.
Journal of forensic and legal medicine 2016 Apr;39;80-4 2016 Apr
Accidental methadone intoxication masquerading as asthma exacerbation with respiratory arrest in a six-year-old boy.
Delaware medical journal 2015 May;87;147-9 2015 May
Effectiveness of naltrexone in the prevention of delayed respiratory arrest in opioid-naive methadone-intoxicated patients.
BioMed research international 2013;2013;903172 2013

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