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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Methimazole

2

III.a Alveolar hemorrhage (AH), diffuse AH (DAH)

1
Last update : 30/08/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist

Publications

Systemic p-ANCA vasculitis with fatal outcome, arising in the setting of methimazole use.
Clinical nephrology. Case studies 2019;7;23-26 2019
Methimazole-induced ANCA-associated vasculitis with diffuse alveolar haemorrhage.
Respirology case reports 2018 Jul;6;e00315 2018 Jul
Necrotizing glomerulonephritis and pulmonary hemorrhage associated with carbimazole therapy.
Thyroid : official journal of the American Thyroid Association 2005 Mar;15;286-8 2005 Mar

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