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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Mitomycin C

3

VI.b Pulmonary arterial hypertension

2
Last update : 08/09/2022
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist

Publications

Recovery from mitomycin-induced pulmonary arterial hypertension.
Annals of the American Thoracic Society 2014 Mar;11;468-70 2014 Mar
Pulmonary hypertension, hemolytic anemia, and renal failure. A mitomycin-associated syndrome.
Chest 1986 Apr;89;608-11 1986 Apr

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