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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Mitomycin C

3

VI.f Hemolytic and uremic syndrome (HUS). See also under Xaf

2
Last update : 30/08/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist

Publications

A review of hemolytic uremic syndrome in patients treated with gemcitabine therapy.
Cancer 1999 May 01;85;2023-32 1999 May 01
Mitomycin C-induced hemolytic uremic syndrome. Six case reports and review of the literature on renal, pulmonary and cardiac side effects of the drug.
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology 1987 Jan;8;33-41 1987 Jan
A syndrome of microangiopathic hemolytic anemia, renal impairment, and pulmonary edema in chemotherapy-treated patients with adenocarcinoma.
Cancer 1986 Oct 01;58;1428-36 1986 Oct 01
Carcinoma-associated hemolytic-uremic syndrome: a complication of mitomycin C chemotherapy.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1985 May;3;723-34 1985 May
Gastric carcinoma and thrombotic thrombocytopenic purpura: association with plasma immune complex concentrations.
British medical journal (Clinical research ed.) 1982 May 15;284;1432-4 1982 May 15

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