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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Nevirapine

1

X.a DRES syndrome - DRESS-like reaction

1
Last update : 09/08/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
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Publications

Nevirapine-induced rash with eosinophilia and systemic symptoms (DRESS).
Indian journal of pharmacology 2013;45;401-2 2013
Persistent high nevirapine blood level with DRESS syndrome 12 days after interruption of antiretroviral therapy.
BMJ case reports 2009;2009; 2009
Nevirapine-associated rash with eosinophilia and systemic symptoms in a child with human immunodeficiency virus infection.
The Pediatric infectious disease journal 2007 Nov;26;1053-6 2007 Nov
Case reports: treatment of nevirapine-associated dress syndrome with intravenous immune globulin (IVIG).
Journal of drugs in dermatology : JDD 2005;4;510-3 2005
Drug rash with eosinophilia and systemic symptoms syndrome and renal toxicity with a nevirapine-containing regimen in a pregnant patient with human immunodeficiency virus.
Obstetrics and gynecology 2003 May;101;1094-7 2003 May
DRESS (drug rash with eosinophilia and systemic symptoms) syndrome associated with nevirapine therapy.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 1998 Nov;27;1321-2 1998 Nov

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