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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Nitrofurantoin

5

III.a Alveolar hemorrhage (AH), diffuse AH (DAH)

1
Last update : 31/08/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist

Publications

Nitrofurantoin-induced pulmonary hemorrhage in a renal transplant recipient receiving immunosuppressive therapy: case report and review of the literature.
The Journal of urology 1994 Sep;152;938-40 1994 Sep
Non fatal pulmonary haemorrhage associated with nitrofurantoin.
Thorax 1987 Jun;42;475-6 1987 Jun
Fatal pulmonary hemorrhage due to nitrofurantoin.
Archives of internal medicine 1980 Feb;140;271-3 1980 Feb

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