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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Muromonab-CD3 (OKT3, orthoclone)

1

XVII.b Opportunistic pulmonary/systemic infections

1
Last update : 31/12/2013
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist

Publications

Influenza A pneumonitis following treatment of acute cardiac allograft rejection with murine monoclonal anti-CD3 antibody (OKT3).
Chest 1995 Nov;108;1456-9 1995 Nov
Increased infections associated with the use of OKT3 for treatment of steroid-resistant rejection in renal transplantation.
Transplantation 1988 Jan;45;68-73 1988 Jan

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