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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Muromonab-CD3 (OKT3, orthoclone)

1

II.b ARDS - Acute lung injury

1
Last update : 20/01/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist

Publications

Is outcome from ARDS related to the severity of respiratory failure?
The European respiratory journal 1997 Jun;10;1297-300 1997 Jun
Sequential therapy--a prospective randomized trial of MALG versus OKT3 for prophylactic immunosuppression in cadaver renal allograft recipients.
Transplantation 1992 Jul;54;50-6 1992 Jul

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