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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Para-aminosalicylic acid (PAS)

1

X.g Hypersensitivity reaction (may manifest with fever and/or skin, throat or airway involvement)

1
Last update : 12/01/2015
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist

Publications

Severe paraaminosalicylic acid hypersensitivity; blood and lymph node studies.
Blood 1955 Jan;10;62-75 1955 Jan
Severe reactions to paraaminosalicylic acid; a case report and brief review of literature.
Annals of internal medicine 1954 May;40;1011-6 1954 May
Allergic reaction to paraaminosalicylic acid; report of case.
Minnesota medicine 1953 Aug;36;850 1953 Aug

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