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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Penicillamine

3

III.b Pneumorenal syndrome (w/wo ANCAs)

1
Last update : 31/08/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist

Publications

ANCA-associated Goodpasture's syndrome in a patient with rheumatoid arthritis on penicillamine.
Indian journal of nephrology 2012 Jan;22;45-7 2012 Jan
Goodpasture-like syndrome induced by D-penicillamine in a patient with systemic sclerosis: report and review of the literature.
The Journal of rheumatology 2003 Jul;30;1616-20 2003 Jul
Antiglomerular basement membrane glomerulonephritis following D-penicillamine-associated nephrotic syndrome.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 1997 Feb;12;325-7 1997 Feb
Goodpasture-like syndrome associated with anti-myeloperoxidase antibodies following penicillamine treatment.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 1995 Oct;10;1925-8 1995 Oct
Goodpasture's syndrome in a patient receiving penicillamine and carbimazole.
Nephron 1987;45;316-20 1987
[Diffuse alveolar hemorrhage and severe glomerulonephritis induced by D-penicillamine. Apropos of a case report with review of the literature].
Therapie 1986;41;297-8 1986
D-penicillamine induced Goodpasture's syndrome in Wilson's disease.
Annals of internal medicine 1975 May;82;673-6 1975 May

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