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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Penicillamine

3

IV.c Obliterative bronchiolitis (a pattern consistent with) (see also IVn, XVx)

2
Last update : 31/08/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
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Publications

Obliterating bronchiolitis in a patient treated with (D)-penicillamine.
Archivos de bronconeumologia 2013 Sep;49;411-2 2013 Sep
Characterisation of severe obliterative bronchiolitis in rheumatoid arthritis.
The European respiratory journal 2009 May;33;1053-61 2009 May
[Obliterating bronchiolitis induced by D-penicillamine in the female patient with systemic scleroderma].
Terapevticheskii arkhiv 2004;76;74-6 2004
Bronchiolitis obliterans in a patient with localized scleroderma treated with D-penicillamine.
The European respiratory journal 1996 Jun;9;1317-9 1996 Jun
Bronchiolitis obliterans: high resolution CT findings and correlation with pulmonary function tests.
Clinical radiology 1993 Apr;47;236-40 1993 Apr
Beneficial effect of intravenous cyclophosphamide and oral prednisone on D-penicillamine-associated bronchiolitis obliterans.
Arthritis and rheumatism 1985 Jan;28;93-7 1985 Jan
Selected adverse reactions of D-penicillamine.
Clinical and investigative medicine. Medecine clinique et experimentale 1984;7;73-6 1984
Upper and lower airway disease in penicillamine treated patients with rheumatoid arthritis.
The Journal of rheumatology 1983 Jun;10;406-10 1983 Jun
Obliterative bronchiolitis in rheumatoid arthritis.
Annals of the rheumatic diseases 1982 Oct;41;469-72 1982 Oct
[The respiratory complications of D-Penicillamine therapy (author's transl)].
Revue francaise des maladies respiratoires 1982;10;7-20 1982
Bronchiolitis and bronchitis in connective tissue disease. A possible relationship to the use of penicillamine.
JAMA 1979 Aug 10;242;528-32 1979 Aug 10
D-penicillamine and obliterative bronchiolitis.
British medical journal 1977 Mar 12;1;713 1977 Mar 12

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