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Diagnosing DIRD
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The Drug-Induced Respiratory Disease Website
Philippe Camus, M.D.
Dijon, France
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Drugs
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Penicillins
5
VII.a
Lymphadenopathy (intrathoracic)
1
Last update :
08/09/2012
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
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Amoxicillin
Antibiotics
Cefazolin
Cefotiam
Cefpodoxime
Ceftaroline
Ceftriaxone
Cephalexin
Cephalosporin(s)
Publications
Hilar and mediastinal lymphadenopathy with hypersensitivity pneumonitis induced by penicillin.