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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Pergolide

3

XII.b Valvular heart disease and/or dysfunction

3
Last update : 10/08/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist

Publications

Valvular heart disease in patients exposed to pergolide: insights from the clinical presentation.
Pharmacoepidemiology and drug safety 2012 Mar;21;276-80 2012 Mar
Combined pergolide-associated valvular heart disease and achilles tendon contractures.
Acta medica academica 2012;41;228-30 2012
Valvular heart disease in patients with Parkinson's disease treated with pergolide, levodopa or both.
Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia 2009 Jan;16;83-7 2009 Jan
Pergolide associated cardiac valvulopathy based on Ontario administrative data.
The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques 2008 May;35;173-8 2008 May
Pergolide-associated valvular heart disease.
Comprehensive therapy 2006;32;94-101 2006
Valvular heart disease in patients taking pergolide.
Mayo Clinic proceedings 2005 Aug;80;1016-20 2005 Aug
The US Food and Drug Administration's registry of patients with pergolide-associated valvular heart disease.
Mayo Clinic proceedings 2003 Jun;78;730-1 2003 Jun
Valvular heart disease in patients taking pergolide.
Mayo Clinic proceedings 2002 Dec;77;1280-6 2002 Dec

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