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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Procainamide

4

V.a Pleural effusion (uni- or bilateral) (can accompany DI-LDs)

1
Last update : 03/09/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist

Publications

Drug-induced lupus.
Toxicology 2005 Apr 15;209;135-47 2005 Apr 15
Clinical organ toxicity of antiarrhythmic compounds: ocular and pulmonary manifestations.
The American journal of cardiology 1999 Nov 04;84;37R-45R 1999 Nov 04
[Procainamide-induced lupus in a patient with bilateral pleural effusion].
Nihon Kokyuki Gakkai zasshi = the journal of the Japanese Respiratory Society 1998 Jun;36;535-40 1998 Jun
Drug-induced lupus pleuritis mimicking pleural space infection.
Chest 1992 Jan;101;268-9 1992 Jan
Pulmonary sequelae in procaine amide induced lupus-like syndrome.
Diseases of the chest 1969 Feb;55;170-2 1969 Feb
Lupus-like syndrome induced by procainamide.
The American journal of cardiology 1967 Sep;20;367-73 1967 Sep

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