The Drug-Induced Respiratory Disease Website
Philippe Camus, M.D.
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Antithymocyte globulin (ATG-ALG) - Antithymocyte immunoglobulin (ATI)
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Drug and radiation history
Drug singularity - Correct identification of the drug
Consistent timing of exposure v. onset of symptoms
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
Careful exlusion of another cause
Remission of symptoms with removal of drug
Recurrence with rechallenge (rarely advisable)
More detailed checklist
An avoidable cause of thymoglobulin anaphylaxis.
Successful desensitization of a patient with aplastic anemia to antithymocyte globulin.
Unexpected death: anaphylactic intraoperative death due to Thymoglobulin carbohydrate excipient.
Pharmacovigilance Analysis of Serious Adverse Events Reported for Biologic Response Modifiers Used as Prophylaxis against Transplant Rejection: a Real-World Postmarketing Experience from the US FDA Adverse Event Reporting System (FAERS).