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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Propylthiouracil (PTU)

4

X.s Vasculitis, pulmonary (w/wo AH), extrapulmonary, systemic: ANCA-positive

3
Last update : 31/05/2013
 
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Diagnosing DIRD
1
Drug and radiation history
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Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
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Causality assessment
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Publications

Myeloperoxidase-specific antineutrophil cytoplasmic antibody-associated vasculitis.
The Lancet. Rheumatology 2024 May;6;e300-e313 2024 May
Propylthiouracil-Induced Antineutrophil Cytoplasmic Antibody-Associated Vasculitis after COVID-19 Vaccination.
Vaccines 2021 Jul 31;9; 2021 Jul 31
Propylthiouracil-induced vasculitis in carbimazole-refractory Graves disease.
The Medical journal of Australia 2019 Jun;210;491-491.e1 2019 Jun
PR3-ANCA: a potential biomarker of disease activity for propylthiouracil-induced ANCA-associated vasculitis.
European journal of dermatology : EJD 2018 Aug 01;28;530-531 2018 Aug 01
A fatal case of propylthiouracil-induced ANCA-associated vasculitis resulting in rapidly progressive glomerulonephritis, acute hepatic failure, and cerebral angiitis.
Clinical nephrology 2015 May;83;309-14 2015 May
Trojan horses: drug culprits associated with antineutrophil cytoplasmic autoantibody (ANCA) vasculitis.
Current opinion in rheumatology 2014 Jan;26;42-9 2014 Jan
Clinical study of renal impairment in patients with propylthiouracil-induced small-vessel vasculitis and patients with primary ANCA-associated small-vessel vasculitis.
Experimental and therapeutic medicine 2013 Jun;5;1619-1622 2013 Jun
Epitope analysis of anti-myeloperoxidase antibodies in propylthiouracil-induced antineutrophil cytoplasmic antibody-associated vasculitis.
Arthritis research & therapy 2013;15;R196 2013
Propylthiouracil-induced cryoglobulinemic vasculitis.
Internal medicine (Tokyo, Japan) 2013;52;2011-2 2013
Propylthiouracil-induced lupus-like or vasculitis syndrome.
Multidisciplinary respiratory medicine 2012 Jul 17;7;14 2012 Jul 17
Recurrent drug-induced ANCA vasculitis in a patient with Crohn's colitis treated with infliximab: a potential contraindication to immunosuppressive therapy.
The American surgeon 2012 Dec;78;1406-8 2012 Dec
Combined ANCA-associated vasculitis and lupus syndrome following prolonged use of hydralazine: a timely reminder of an old foe.
International urology and nephrology 2010 Jun;42;503-6 2010 Jun
Antineutrophil cytoplasmic antibody-positive vasculitis in a patient with graves disease: cross-reaction between propylthiouracil and methimazole.
Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists 2010;16;449-51 2010
PTU-associated vasculitis in a girl with Turner Syndrome and Graves' disease.
Pediatric emergency care 2006 Jan;22;52-4 2006 Jan
Propylthiouracil and antineutrophil cytoplasmic antibody associated vasculitis: the detective finds a clue.
Seminars in arthritis and rheumatism 2006 Aug;36;1-3 2006 Aug
Propylthiouracil-induced antineutrophil cytoplasmic antibody-associated crescentic glomerulonephritis in a patient with a predisposition to autoimmune abnormalities.
Modern rheumatology 2003 Jun;13;173-6 2003 Jun
Anti-neutrophil cytoplasmic autoantibody (ANCA) profiles in propylthiouracil-induced lupus-like manifestations in monozygotic triplets with hyperthyroidism.
Scandinavian journal of rheumatology 2002;31;46-9 2002
Drug-associated antineutrophil cytoplasmic antibody-positive vasculitis: prevalence among patients with high titers of antimyeloperoxidase antibodies.
Arthritis and rheumatism 2000 Feb;43;405-13 2000 Feb
Diffuse alveolar hemorrhage and pulmonary capillaritis due to propylthiouracil.
Chest 1999 Nov;116;1485-8 1999 Nov
Alternating antineutrophil cytoplasmic antibody specificity: drug-induced vasculitis in a patient with Wegener's granulomatosis.
Arthritis and rheumatism 1999 Feb;42;384-8 1999 Feb
Antineutrophil cytoplasmic antibody-positive crescentic glomerulonephritis associated with anti-thyroid drug treatment.
British journal of rheumatology 1995 Nov;34;1090-1 1995 Nov

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