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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Propylthiouracil (PTU)

4

X.x Subclinical ANCA positivity

3
Last update : 04/12/2013
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
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Publications

Epitope analysis of anti-myeloperoxidase antibodies in propylthiouracil-induced antineutrophil cytoplasmic antibody-associated vasculitis.
Arthritis research & therapy 2013;15;R196 2013
Propylthiouracil and antineutrophil cytoplasmic antibody associated vasculitis: the detective finds a clue.
Seminars in arthritis and rheumatism 2006 Aug;36;1-3 2006 Aug
Occurrence of antineutrophil cytoplasmic antibodies and associated vasculitis in patients with hyperthyroidism treated with antithyroid drugs: A long-term followup study.
Arthritis and rheumatism 2005 Feb 15;53;108-13 2005 Feb 15
Anti-neutrophil cytoplasmic autoantibody (ANCA) profiles in propylthiouracil-induced lupus-like manifestations in monozygotic triplets with hyperthyroidism.
Scandinavian journal of rheumatology 2002;31;46-9 2002
Frequency of appearance of myeloperoxidase-antineutrophil cytoplasmic antibody (MPO-ANCA) in Graves' disease patients treated with propylthiouracil and the relationship between MPO-ANCA and clinical manifestations.
Clinical endocrinology 2001 May;54;651-4 2001 May

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