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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Propylthiouracil (PTU)

4

X.ak Dual MPO-/PR3-ANCA systemic disease/vasculitis/pseudovasculitis

1
Last update : 08/05/2015
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist

Publications

Propylthiouracil-Induced Antineutrophil Cytoplasmic Antibody-Positive Vasculitis and Agranulocytosis: A Rare Case with Life-Threatening Multiple Systemic Manifestations.
Endocrinology and metabolism (Seoul, Korea) 2023 Apr;38;282-284 2023 Apr
PR3-ANCA: a potential biomarker of disease activity for propylthiouracil-induced ANCA-associated vasculitis.
European journal of dermatology : EJD 2018 Aug 01;28;530-531 2018 Aug 01
Propylthiouracil induced ANCA-associated vasculitis in a 14-year-old girl.
Acta clinica Belgica 2015 Apr;70;127-9 2015 Apr

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