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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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All-transretinoic acid (ATRA)

4

II.b ARDS - Acute lung injury

2
Last update : 07/07/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Arsenic trioxide (As2O3)
3

Publications

Pathophysiology, clinical features and radiological findings of differentiation syndrome/all-trans-retinoic acid syndrome.
World journal of radiology 2014 Aug 28;6;583-8 2014 Aug 28
Differentiation syndrome in promyelocytic leukemia: clinical presentation, pathogenesis and treatment.
Mediterranean journal of hematology and infectious diseases 2011;3;e2011048 2011
All-trans retinoic acid syndrome: another cause of drug-induced respiratory failure.
Southern medical journal 2007 Sep;100;899-902 2007 Sep
Drug-induced respiratory disease: "the great mimicker".
Southern medical journal 2007 Sep;100;863-4 2007 Sep
Radiologic features of all-trans-retinoic acid syndrome.
AJR. American journal of roentgenology 2002 Feb;178;475-80 2002 Feb
All-trans retinoic acid syndrome: chest CT assessment.
European radiology 2001;11;1516-7 2001
Respiratory failure during induction chemotherapy for acute myelomonocytic leukaemia (FAB M4Eo) with ara-C and all-trans retinoic acid.
British journal of haematology 2000 Jun;109;847-50 2000 Jun
Clinical description of 44 patients with acute promyelocytic leukemia who developed the retinoic acid syndrome.
Blood 2000 Jan 01;95;90-5 2000 Jan 01
Incidence, clinical features, and outcome of all trans-retinoic acid syndrome in 413 cases of newly diagnosed acute promyelocytic leukemia. The European APL Group.
Blood 1998 Oct 15;92;2712-8 1998 Oct 15

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