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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Rituximab

5

X.f Anaphylaxis-Anaphylactoid reaction (can be fatal)

1
Last update : 29/09/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Anti-CD20 antibody therapy
4

Publications

Drug-specific Th2 cells and IgE antibodies in a patient with anaphylaxis to rituximab.
International archives of allergy and immunology 2012;159;321-6 2012
Acute respiratory distress syndrome during the third infusion of rituximab in a patient with follicular lymphoma.
International journal of hematology 2004 Aug;80;164-7 2004 Aug
Combined fludarabine and rituximab for low grade lymphoma and chronic lymphocytic leukemia.
Leukemia & lymphoma 2003 Mar;44;477-81 2003 Mar

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