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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Rituximab

5

I.d Organizing pneumonia pattern (an area or areas of consolidation on imaging)

2
Last update : 20/01/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
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See also under
Anti-CD20 antibody therapy
4

Publications

Rituximab-induced bronchiolitis obliterans organizing pneumonia.
Case reports in medicine 2012;2012;680431 2012
Rituximab-induced lung disease: A systematic literature review.
The European respiratory journal 2010 Mar;35;681-7 2010 Mar
Cryptogenic organizing pneumonia after rituximab therapy for presumed post-kidney transplant lymphoproliferative disease.
Pediatric nephrology (Berlin, Germany) 2010 Jun;25;1163-7 2010 Jun
Recurrent fevers, cough, and pulmonary opacities in a middle-aged man.
Chest 2010 Jun;137;1465-9 2010 Jun
Rituximab (B-cell depleting antibody) associated lung injury (RALI): a pediatric case and systematic review of the literature.
Pediatric pulmonology 2009 Sep;44;922-34 2009 Sep
Organizing pneumonia after rituximab therapy: Two cases.
Joint bone spine 2008 May;75;362-5 2008 May
Bronchiolitis obliterans with organizing pneumonia after rituximab therapy for non-Hodgkin's lymphoma.
Hematological oncology 2006 Dec;24;234-7 2006 Dec

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