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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Tryptophan (l-tryptophan, synthetic)

5

VI.b Pulmonary arterial hypertension

2
Last update : 24/08/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist

Publications

Dietary pulmonary hypertension.
Thorax 1994;49 Suppl;S33-8 1994
Pulmonary manifestations of the eosinophilia-myalgia syndrome associated with tryptophan ingestion.
Chest 1992 May;101;1274-81 1992 May
Pulmonary hypertension in a patient with tryptophan-induced eosinophilia-myalgia syndrome.
The American journal of medicine 1991 Feb;90;272-3 1991 Feb
Pulmonary disease associated with L-tryptophan-induced eosinophilic myalgia syndrome. Clinical and pathologic features.
Chest 1990 May;97;1032-6 1990 May

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