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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Sufentanil

2

IX.d Respiratory failure from ventilatory depression (due to neuromuscular blockade/paralysis)

2
Last update : 13/09/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist

Publications

[Respiratory depression after an accidental large dose of intrathecal sufentanil].
Annales francaises d'anesthesie et de reanimation 2009 Oct;28;903-4 2009 Oct
Respiratory arrest after intrathecal injection of sufentanil and bupivacaine.
Acta anaesthesiologica Scandinavica 2004 Jul;48;793-4 2004 Jul
Respiratory arrest in a parturient following intrathecal administration of fentanyl and bupivacaine as part of a combined spinal-epidural analgesia for labour.
Anaesthesia 2002 Sep;57;939-40 2002 Sep
Respiratory arrest during caesarean section after intrathecal administration of sufentanil in combination with 0.1% bupivacaine 10 ml.
Anaesthesia and intensive care 2002 Oct;30;698-9 2002 Oct
Respiratory arrest following intrathecal injection of sufentanil and bupivacaine in a parturient.
Canadian journal of anaesthesia = Journal canadien d'anesthesie 1998 Sep;45;880-3 1998 Sep
Respiratory depression after 5 micrograms of intrathecal sufentanil.
Anesthesia and analgesia 1998 Dec;87;1377-8 1998 Dec
Risk of respiratory arrest after intrathecal sufentanil.
Anesthesia and analgesia 1997 Nov;85;1088-90 1997 Nov
Severe respiratory depression in the obstetric patient after intrathecal meperidine or sufentanil.
International journal of obstetric anesthesia 1997 Jul;6;182-4 1997 Jul
Respiratory arrest in a parturient following intrathecal injection of sufentanil and bupivacaine.
Anaesthesia 1996 Feb;51;173-5 1996 Feb

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