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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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BCG therapy (topical instillations in the urinary bladder)

5

I.a Pneumonitis (ILD), acute and/or severe (may cause ARDS)

2
Last update : 08/07/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist

Publications

Drug-induced interstitial pneumonia after intravesical Bacillus Calmette-Guerin administration for bladder cancer with scleroderma.
IJU case reports 2023 Mar;6;133-136 2023 Mar
Complications following intravesical bacillus Calmette-Guerin treatment for bladder cancer: a case series of 22 patients.
Infectious diseases (London, England) 2015;47;725-31 2015
Severe pneumonia after intravesical BCG instillation in a patient with invasive bladder cancer: case report and literature review.
Monaldi archives for chest disease = Archivio Monaldi per le malattie del torace 2013 Mar;79;44-8 2013 Mar
Multi-organ failure with atypical liver granulomas following intravesical Bacillus Calmette-Guerin instillation.
World journal of hepatology 2011 Mar 27;3;79-82 2011 Mar 27
Diffuse alveolar damage in BCGosis: a rare complication of intravesical bacillus Calmette-Guérin therapy for transitional cell carcinoma.
Pathology 1999 Feb;31;55-6 1999 Feb
Bacillus Calmette-Guerin (BCG) immunotherapy for bladder cancer: review of complications and their treatment.
The Australian and New Zealand journal of surgery 1998 May;68;340-4 1998 May

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