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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Benzylthiouracil

1

III.d Alveolar hemorrhage, diffuse (ANCA-positive/-related)

1
Last update : 11/10/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
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Publications

Benzylthiouracil induced ANCA associated glomerulonephritis in patients with graves' disease.
La Tunisie medicale 2015 Nov;93;696-701 2015 Nov
Prevalence of antineutrophil cytoplasmic antibodies during treatment with benzylthiouracil.
Pathologie-biologie 2009 Jul;57;410-4 2009 Jul
[Benzylthiouracil induced ANCA-positive vasculitis: study of three cases and review of the literature].
Annales d'endocrinologie 2008 Dec;69;517-22 2008 Dec
ANCA-associated diffuse alveolar hemorrhage due to benzylthiouracil.
European journal of pediatrics 2006 Jul;165;435-6 2006 Jul

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