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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Adalimumab

3

X.s Vasculitis, pulmonary (w/wo AH), extrapulmonary, systemic: ANCA-positive

1
Last update : 01/11/2014
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
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Careful exlusion of another cause
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Remission of symptoms with removal of drug
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Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
TNF-alpha antagonists / inhibitors
5

Publications

Adalimumab-induced Anti-neutrophilic Cytoplasmic Antibody Vasculitis: A Rare Complication of an Increasingly Common Treatment.
Cureus 2019 Sep 09;11;e5598 2019 Sep 09
Antineutrophil cytoplasmic antibodies associated vasculitis in patient with Crohn's disease treated with adalimumab.
Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia 2017;37;560-561 2017
[Antineutrophil cytoplasmic antibody associated vasculitis in a patient treated with adalimumab for a rheumatoid arthritis].
Nephrologie & therapeutique 2009 Dec;5;652-7 2009 Dec

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