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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Bortezomib

2

III.a Alveolar hemorrhage (AH), diffuse AH (DAH)

1
Last update : 07/07/2013
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist

Publications

Early-Onset Severe Diffuse Alveolar Hemorrhage after Bortezomib Administration Suggestive of Pulmonary Involvement of Myeloma Cells.
Journal of clinical and experimental hematopathology : JCEH 2015;55;163-8 2015
Bortezomib-related diffuse alveolar hemorrhage.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2012 Dec 20;30;e379-81 2012 Dec 20
Severe pulmonary complications after bortezomib treatment for multiple myeloma: an unrecognized pulmonary vasculitis?
Leukemia research 2007 Jul;31;1027-8 2007 Jul

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