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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Cisplatin

3

VI.f Hemolytic and uremic syndrome (HUS). See also under Xaf

2
Last update : 05/05/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist

Publications

Haemolytic uraemic syndrome following chemotherapy for an unusual germ-cell tumour.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 1999 Jul;14;1786-8 1999 Jul
Haemolytic uraemic syndrome associated with bleomycin, epirubicin and cisplatin chemotherapy--a case report and review of the literature.
Acta oncologica (Stockholm, Sweden) 1998;37;107-9 1998

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